Compensate a little, but punish a lot: Asymmetric routes to restoring justice

Spending a little to save a lot

Phase III studies of disease-modifying agents for neurodegenerative disorders generally require hun­ dreds of patients to be followed for at least 2 years at a cost of millions of dollars. No matter how promis­ ing an agent may appear in preclinical studies and animal models, preliminary evidence that the treat­ ment is likely to be helpful in patients (proof-of­ concept) and that it is reasona...

Give a little ... get a lot.

Futility studies: spending a little to save a lot.

published by admin on Mon, 09/08/2014 3:07pm Title Futility studies: spending a little to save a lot. Publication Type Journal Article Year of Publication 2006 Authors Schwid, SR, Cutter, GR Journal Neurology Volume 66 Issue 5 Pagination 626-7 Date Published 2006 Mar 14 ISSN 1526-632X

How to Net a Lot with Little : Small " - Nets for

It is known that in general range spaces of VC-dimension d > 1 require "-nets to be of size at least (d " log 1 "). We address the question whether this general lower bound is valid for the special range spaces that typically arise in computational geometry. We show that disks and pseudo-disks in the plane as well as halfspaces in R 3 allow "-nets of size only O(1 "), which is best possible up ...

A Variance Explanation Paradox: When a Little is a Lot

Concerning a single major league at bat, the percentage of variance in batting performance attributable to skill differentials among major league baseball players can be calculated statistically. The statistically appropriate calculation is seriously discrepant with intuitions about the influence of skill in batting performance. This paradoxical discrepancy is discussed in terms of habits of th...